Here are things we do to try for top MPG on ASET's , adjust the valves(and jakes) and install new rocker arm hold down bolts( due to possible breakage), replaced the boost pressure relief valve on the intake manifold ( if you havent already replaced it), load the newest software and datafiles in both ECM's ( step 12B as its called ), calibrate throttle pedal and VGT turbo, pressure test the complete intake system including the EGR cooler piping, replaced the muffler with a Walker straight through muffler ( still quite), make sure there are coolant shutoffs on the fuel heater for summertime (keep them closed till it gets real cold), Figure out what MPH you want to run/cruise and talk to a good salesman how knows all the fourmulas for getting the correct tire size for the rear gear ratio and trans that you have. Sometimes a simple tire size change (without changing wheels) can get you into the "sweet spot" you to be for best MPG. We have seen trucks that were spec'ed correctly to begin with but the new customer wants to be like all his bullhauling buddies and went from 22.5 lo-pro to 24.5 full size just to be cool, but didn't realize he just screwed up his sweet-spot and now has low power complaints. Get low rolling restiance tires if possible. Make sure the hole in the hood meets up with the air filter housing ( marking paint on the rubber bellows and close and latch the hood) a good seal so it's not sucking hot air off of the engine in the summertime. Some of those aftermarket chrome hood louvers restrict to much air on the higher HP engine( says on the package). And of course dont be running 80+ MPH, keep it as slow as you can sainly deal with. Some guys say changing the governer setting (in the ECM) to all-speed instead of min-max helps the MPG and I have seen it help once but the guy was already a slow and steady driver so not totally sure on that one. Thats all I can think of for now but I'm sure I'm leaving somethings out.